Dihydrotestosterone in women and men: functions, causes of increase and decrease

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Dihydrotestosterone is the most powerful male sex hormone. In men, it is synthesized by the action of the enzyme 5-alpha reductase on testosterone. Most of dihydrotestosterone is produced in the testicles. In the female body, another hormone is used to form dihydrotestosterone, namely, androstenedione. It is produced by the adrenal glands.

A small part of it is produced by the ovaries. In male organisms, DHT determines the characteristics of the young man’s physical development during puberty. This hormone is responsible for potency and sexual behavior, the development of the prostate and genitals. The highest level of this hormone is found in the hair follicles and skin of the genitals. If dihydrotestosterone is elevated in the human body, various diseases can develop because of this.

The role of dihydrotestosterone in the human body

Before considering the causes of dihydrotestosterone increase in men and women, it is necessary to have a general idea of the role of this hormone in the human body. Dihydrotestosterone, as well as many other male hormones, has a direct impact on the physical development of the guy, the presence of hair on the body and face, the formation and development of the genitals and prostate gland, sexual behavior, etc.

The highest percentage of this hormone is formed in tissues that are located beyond the borders of the testes. The highest content of DHT in men, as already noted, is observed in the skin of the reproductive organs and hair follicles.

In men, this hormone has a stimulating effect on the proliferation of prostate cells. In case of deviation of the content of this hormone from the norm, various diseases appear, including prostate tumors. If the level of dihydrotestosterone in men becomes higher than normal, then such patients are usually assigned inhibitors to 5-alpha reductase. Such drugs inhibit the synthesis of 5-alpha reductase, due to which the content of dihydrotestosterone in the blood of men is reduced. The rate for men depends on age and a number of other factors that are necessarily taken into account when passing the analysis.

In the female body, dihydrotestosterone is produced in the tissues of the adrenal glands. Among the male androgen is 5 hormones, of which only testosterone and dihydrotestosterone have a direct effect on the body. The remaining 3 hormones are classified as pro-hormones, that is, they begin to affect the body only after "turning" into testosterone.

If dihydrotestosterone in the woman’s body becomes above the permissible level, the girl will begin to develop symptoms of hyperandrogenism, such as:

hirsutism is a pathology in which hair grows very intensively and where women usually do not appear,
acne
a significant increase in clitoral size.

If the hormone is constantly kept above the norm during adolescence, girls may experience impaired skeletal formation (it develops in the male type), the absence of menstruation or a violation of the cycle, the voice may become rough. In older women, the content of dihydrotestosterone above the norm can lead to the development of infertility and baldness.

If the hormone is contained in an insufficient amount, special preparations may be prescribed to the patient, after which it will be used higher. Deviations of dihydrotestosterone from the norm can be congenital or acquired.

Both in women and men, the growth of dihydrotestosterone above the norm leads to slower hair growth, deterioration of their condition and baldness.

Norm and deviations

To determine the content of dihydrotestosterone in the blood of men and women, venous blood analysis is performed. In the course of this analysis, the serum concentration of DHT is established by enzyme immunoassay. The rate in women and men varies according to age.

with hypergonadism,
while taking hormonal drugs,
with prostate adenoma,
during pregnancy in women
in the presence of tumors in the gonads and adrenal glands,
with hirsutism.

To clarify the reasons for which the level of this hormone has become elevated, a special analysis is submitted. This analysis can be assigned in the following cases:

with reduced androgen content,
at low levels of 5-alpha reductase,
while reducing sexual desire and impaired potency,
in the presence of symptoms characteristic of prostatic hyperplasia (impaired urination, enlarged prostate, etc.),
during treatment with drugs that include 5-alpha reductase inhibitors,
with rapid baldness,
while reducing the size of the male testicles, unnaturally small penis, lack of hair in the armpits and pubic hair,
with violations of the menstrual cycle, the presence of acne and seborrhea symptoms,
adolescents in puberty.

Dihydrotestosterone and testosterone are interrelated hormones, therefore, as a rule, the content of both the first and second is simultaneously checked.

Using analysis to diagnose various diseases

If the level of dihydrotestosterone in the blood is elevated, this may indicate the presence of certain diseases. In such situations, to confirm the diagnosis, an analysis is performed on the content of DHT in the blood. Among the diseases that lead to an increase in dihydrotestosterone levels, the following are distinguished:

hypogonadism in men
benign prostatic hyperplasia,
hereditary disorders of 5-alpha rectase production,
Morris syndrome (it is characterized by a lack of susceptibility to androgens),
androgen deficiency, triggered by age-related changes - in such cases, impotence is rapidly developing in men, and libido decreases in women.

In the presence of benign prostatic hyperplasia, the analysis of dihydrotestosterone is taken to monitor the patient's condition and monitor changes when using drugs that include 5-alpha reductase inhibitors. Women in most cases pass such an analysis to establish the cause of the appearance of hyperandrogenic dermopathy.

Increased dihydrotestosterone in men: the causes and how to lower the level

Visible masculinity, the brutality of men, physical strength - the merit of the hormone produced in the male body (mainly in the testicles) of testosterone when exposed to enzymatic reactions.

This hormone is dihydrotestosterone, the level of which in some cases may exceed normal levels.

DGT is involved in the formation of a general constitutional type of a young man's figure, the development of the genitals, prostate gland, the appearance of hair distribution, sexuality, and the level of potency. The tissues, muscles and bones of the skeleton are supported by the work of this hormone.

Recommendations for preparing for the analysis

Analysis of the content of dihydrotestosterone should be taken in the morning, preferably between 8 and 11 o'clock, on an empty stomach. Before passing the analysis, you can drink non-carbonated water. From the use of tea, coffee, soda and juice is better to refuse. On the evening before the test is not recommended to eat fatty foods.

1-2 days before taking a blood test for dihydrotestosterone it is necessary to refrain from drinking alcohol and cigarettes, not to lift heavy objects, not to engage in active sports. It is recommended to stop taking medications, but this must be previously agreed with the doctor.

Half an hour before the blood test, the patient needs to calm down, take a comfortable posture and relax. Stressful situations and emotional outbursts on the eve of the analysis are contraindicated.

It is impossible to take a blood test for dihydrotestosterone after ultrasound and X-ray examinations, massage and physiological procedures, etc.

Testosterone tests are taken several times at regular intervals.

To track the results of treatment, each subsequent analysis should be given in the same conditions, in the same place and at the same time.

If at the time of testing for dihydrotestosterone a person cannot stop taking medication, you must inform the doctor about it, because some drugs may distort the results of the analysis.

Women are best tested for the content of dehydrotestosterone at the beginning of the menstrual cycle.

How is the treatment carried out?

The fact that the level of DHT is elevated can only be determined by a doctor after a detailed study of the test results. Based on the results obtained, appropriate treatment will be prescribed. In most cases, various hormone preparations are prescribed. Specific drugs and the duration of treatment is determined by the doctor.

It must be remembered that any hormonal imbalance can lead to very serious health problems. With an increase in the content of dihydrotestosterone in the blood, competent and timely treatment is necessary. So react to all the signals of your body and do not postpone the visit to the hospital. Good luck and be healthy!

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Background and Functions of Dihydrotestosterone

Dihydrotestosterone is synthesized by the interaction of the enzyme 5-alpha reductase (5-AR) and testosterone, which results in the addition of 2 hydrogen atoms to the latter (hence the prefix "dihydro"). The more free testosterone, the more its active form. About 70% of DHT is formed in peripheral tissues. Unlike testosterone, dihydrotestosterone 3-4 times more actively binds to androgen receptors, forms a stable complex with them, which ensures its more pronounced effect at low concentrations (10% of the level of testosterone circulating in the blood). The bulk of DHT is concentrated in the hair follicles, groin and prostate skin. The highest degree of activity is manifested in the brain, genitals, skin.

The main functions of dihydrotestosterone:

Active androgen receptors are abundant in nerve cells, therefore dihydrotestosterone has a significant regulatory effect on the functioning of the central nervous system,
Promotes compaction and muscle growth due to nervous regulation (testosterone has a more pronounced anabolic effect),
Responsible for male-type hair growth, sebaceous gland activity, development of the genital organs,
Increases resistance to both physical and psychological stress
Regulates the level of libido and the quality of erection.

An important function of dihydrotestosterone in the male body is estrogen protection. DHT blocks aromatase activity, with the participation of which androgens are transformed into estrogen.Men taking 5-AR inhibitors often notice manifestations of gynecomastia (breast augmentation) - a consequence of a lack of DHT.

Dihydrotestosterone in men also regulates the activity of prostate tissue cell division, so an excess of this hormone often leads to hyperplasia of the gland and its oncological degeneration.

Symptoms and causes of abnormalities

The normal level of dihydrotestosterone (reference values) in adult males is 250 - 990 pg / ml. That indicator below normalA number of symptoms indicate:

Slowing puberty in adolescents.
Decreased muscle volume, fat deposition at the hips and abdomen, breast augmentation.
Decreased libido, worsening erections.
Stopping or slowing body hair growth.

The causes of low levels of dihydrotestosterone may be primary and secondary hypogonadism. - lack of androgens due to congenital or acquired pathologies. Other factors:

Reception of inhibitors 5-AR. Some have a congenital deficiency of this enzyme,
Hypogonadism,
Andropause (natural age-related decrease in testosterone levels).

ABOUT elevated level The following signs indicate dihydrotestosterone:

Earlier baldness. Excessive DHT causes dystrophy of the hair follicles, as a result of which the hair changes color, becomes thinner, and then falls out. Moreover, the temples and the neck almost do not suffer, hair loss begins with the forehead and parietal part. The sensitivity of onion cells to dihydrotestosterone is determined genetically and is transmitted through the maternal lineage (“alopecia gene” - Sox21).
Oily facial skin, acne ("Hormonal acne"). Increased dihydrotestosterone provokes the sebaceous gland (more precisely, its cells - sebocytes, on the surface of which there are androgenic receptors) to intensive production of sebum. As a result, a pore blockage occurs, thereby creating a favorable environment for the development of bacteria.
Pallor of the skin.

Men who have elevated dihydrotestosterone are often different. unreasonable aggressiveness, temper, unbalanced character.

Provocative factors of high dihydrotestosterone are:

Taking steroid drugs
Morris syndrome (congenital lack of response to androgens)
Tumors of the adrenal glands and testicles,
Hypergonadism,
BPH.

If there is evidence of imbalance dihydrotestosterone, you should contact your urologist, andrologist or general practitioner.

Diagnostics

Determining the level of dihydrotestosterone is performed by enzyme immunoassay (ELISA). The cost of the study depends on the status of the medical institution and its territorial location. Average the price is 1300 p. The result of the analysis on dihydrotestosterone can be found after 7-9 days.

Indications for diagnosis are:

Suspected adenoma or the need to control the state of the prostate gland during the treatment of hyperplasia.
Alopecia (alopecia).
Signs of lack or excess of androgens.

Terms of preparation for the analysis:

8 hours before the blood can only drink non-carbonated water, food and other beverages are excluded.
Half an hour before the analysis should not be emotionally or physically overstrained, as well as smoking.
During the day, exclude alcoholic and caffeinated beverages.

It is important to inform the doctor about taking testosterone drugs or 5-alpha reductase inhibitors. For the purity of the result, the course treatment with these agents can be interrupted.

When dihydrotestosterone deviates from the norm, additional examinations are appointed: ultrasound of the pelvic organs, prostate, and testicles.

The tactics of treatment is determined by the results of diagnosis, the age of the patient and the presence of comorbidities.

What happens when balance and imbalance

With a sufficient amount of DHT, the man behaves confidently, is physically well developed, the body is tightened, the muscle mass is formed normally. Excess fat is not formed.

If the hormone is not enough, then men have a low level of sexual desire. Increased dihydrotestosterone contributes to hormonal balance, forcing sensitive receptors to react to its presence.

And since it concentrates mostly in the hair follicles and in the skin of the genital organs, the imbalance of dihydrotestosterone in the body of a man is manifested by hair loss, sometimes diabetes mellitus and prostate gland diseases, when the formation of tumors is observed (up to prostate cancer).

Cases of depression are often explained by the permanent excess of dihydrotestosterone, which the man did not guess.

Etiological factors

Physiological processes or diseases in which dihydrotestosterone is elevated:

Treatment with hormonal drugs, affecting including the level of the hormone dihydrotestosterone.
Genetic factors, such as hypergonadism.
Prostate adenoma in men.
Microadenoma of the brain (pituitary).
Tumor processes of the genital glands.
Hepatoplastoma.
Inadequate liver function or tumor processes in the adrenal glands.

If women have a jump in DHT can be triggered by a dose of Postinor, then in men the situation is more serious.

Observed external signs are not harmless - an imbalance, when dihydrotestosterone is elevated or reduced, can be a mirror of the pathological phenomena occurring in the depth of the body, sometimes carrying a threat to life.

To prevent the development of serious diseases, be careful of any manifestations of irregularity when they begin to appear. The detected disease is treated in a simpler and faster manner than when it was launched.

An increase in the hormone can be observed with prostate adenoma.

But dihydrotestosterone is elevated in men not always due to a serious illness. Sometimes deviations from the norm are fixed when a patient is treated with a 5-alpha reductase inhibitor (its amount is related to the production of DHT).

If the fact that dihydrotestosterone levels are elevated, as well as the causes that have affected it, is found, it is necessary to immediately begin treatment and lowering the index.

Reducing the value is necessary to the male norm of this hormone, which has a differentiation by age.

The norm of dihydrotestosterone for men is within the broad limits of 25-990 pg / ml, taking into account only specialist clear nuances, and therefore it is not recommended to make a diagnosis yourself.

Refer to the clinic at the place of residence - this will speed up the diagnosis and protect you from aggravating the pathological processes.

Course troubleshooting

Medicine has not yet learned how to prevent the very possibility of hormonal disruptions, but timely treatment can quickly normalize the patient's condition.

Which doctor should I contact? With increased levels of dihydrotestosterone in men, recommendations are given by specialists - the urologist and endocrinologist.

How to lower the level of DHT depends largely on the cause of its increase, the clinical features and the condition of other organs in the patient's body.

The treatment scheme is always individual, since the endocrine processes are fragile and interrelated. Only an experienced endocrinologist will be able to determine the whole complex of interrelated details, and he will select the therapy.

It is often practiced the appointment of hormonal drugs, taking into account the subtle fluctuations in the imbalance of the patient's own hormones.

Unlike women, for whom in such cases there is only one remedy - Diane 35, male patients are treated in a complex, using different therapeutic areas.

At increase of hormone it is recommended to address to the urologist or the endocrinologist.

As an option, men with elevated levels of DHT may be prescribed intake of inhibitors (suppressors) to 5-alpha reductase. Among them are Buserelin, Deslorelin. They help reduce the content of dihydrotestosterone. Other possible medications are Medroxyprogesterone, spironolactone. Ketonazole. But all these appointments should be made only by the attending physician.

Remember the danger of harming the health of inept self-treatment is much more than the existing disease.

As a natural medicine, you can use medicinal antiandrogenic plants, reducing the production and synthesis of DHT:

Pumpkin seeds and green tea.
Linseed oil and stevia.
Vitamins C, B6 and wormwood.
Milk thistle and fenugreek.

If the picture of the disease is complemented by obesity, the composition of drug therapy include a diet with a low amount of carbohydrates. Sometimes even this small measure contributes to the contribution to the normalization of hormonal balance.

Mensgen.ru "Hormones" Why there is an increase in dihydrotestosterone and how to reduce it in the male body

Dihydrotestosterone in men: functions, normal levels and deviations

Dihydrotestosterone in men is a hormone that is produced from testosterone under the influence of enzymatic reactions. There are some the differences between testosterone anddihydrotestosteronethat affect the function of hormones in the body. DTG controls the normal functioning of the prostate and all organs of the urogenital system.

Dihydrotestosterone responsible for the timely appearance of secondary sexual characteristics in boys and with age, its concentration in the body may change.

Deviation of the level of the hormone from the norm may indicate a variety of pathologies, so it is important to regularly undergo research and monitor the levels of DHT in the blood.

Discover, dihydrotestosterone — whatit is and what value it has for men, you can have a urologist.

Dihydrotestosterone functions

What is the difference testosterone from dihydrotestosterone, and what functions such hormones perform in the body? Dihydrotestosterone is a hormone that is produced in a man.

Compared with testosterone, it interacts more with cell receptors, so its androgenic activity is much more noticeable.

This substance has a significant impact on the development and functioning of the prostate in the future, so in medical practice it is widely used to eliminate prostate diseases.

In that case, if the concentration of dihydrotestosterone in the male body greatly increases and exceeds the permissible norms, then there is a noticeable increase in the prostate in size. In addition, various pathologies begin to progress and tumor-like formations in prostate tissues are detected.

The concentration of dihydrotestosterone is determined by the production and content of testosterone in the male body. The higher the content of the latter, the greater its quantity is fermented in DHT. It is necessary to maintain a normal level of such a hormone due to the control of testosterone, the production of which is controlled by the hypothalamus and pituitary gland.

Dihydrotestosterone is actively involved in the development and operation of other organs, as well as having a direct impact on biological and physiological processes. This hormone controls the state of the genital organs, muscle mass, hair follicles and the skeletal system.

DHT has a positive effect on physical development during adolescence and not only in the aspect of secondary symptoms. Such a hormone contributes to the acceleration of the formation of muscle mass and the decomposition of fat. DGT affects a man’s sexual behavior, so his lack of body becomes one of the causes of impotence and decreased libido.

Symptoms of abnormalities

The very first symptom indicating that increased dihydrotestosterone in men become problems with hair.

In other words, the hair falls out, their growth slows down and over time the man becomes bald.

Such a hormone in the male body affects other tissues and organs, so a violation of its content is accompanied by the appearance of certain symptoms.

The hormone deficiency in boys causes pronounced disruptions in sexual development. These children do not have hair in the armpits and other parts of the body, and there are abnormalities in the structure of the penis. In addition, there is a lack of muscle mass, and a member or testicles are greatly reduced in size.

In case if dihydrotestosterone in mendowngradedthen some femininity, disproportion of the limbs and inconsistency of the figure may appear.

Usually such patients are distinguished among people with an apathetic and quarrelsome character, and are strongly closed in themselves.

The lack of DHT in men leads to the fact that reduced sexual desire and disturbed potency, up to problems with erection.

In case if dihydrotestosterone is elevated in menthen nothing good comes of it either. In men, there is a bright imbalance of hormones, the growth of hair on the head stops and active baldness is observed.

Boost dihydrotestosterone levels in men even a few pg / ml is accompanied by too tall a teenager, an underdevelopment of his throat and heightened pallor of the skin

Dihydrotestosterone and the female body

To understand the role of dihydrosterone in a woman's body, it is necessary to understand what it is and how it is formed.

You will forget about diseases of the thyroid gland, if you wake up in the morning to drink 1 cup.

Dihydrotestosterone - This is a male hormone, which, along with female hormones, is dominated by blood. Androgen, that is, the male hormone, is released adrenal gland and partially ovaries. It is formed from testosterone (male sex hormone) with the participation of a special enzyme, a protein compound - 5 alpha reductase.

Dihydrotesterone is more potent than testosterone and is very important for the female body.

The role of DHT in the female body:

participates in the sebaceous glands and the regulation of sweating,
responsible for the growth of hair, muscle and bone tissue of a woman,
regulates female libido,
It is an integral part of fat, protein and carbohydrate metabolism in the body.

Norma dihydrotestosterone in women and men

To determine any deviations in the production of dihydrotestosterone in the body of a woman or a man, specialists use standard indicators. The concentration of dihydrosterone in the female body is determined using a clinical blood test, then the indicators are compared with the standard.

Table of norms indicator dihydrotestosterone in men and women by age:

In women of reproductive age, digidoresterone is considered the norm, which is within 24-250 pg / mlhowever, in the postmenopausal period, this figure is slightly reduced. The peak activity of dihydrotestosterone in the body falls on the adolescent transitional period, when puberty occurs. At this stage, the level of dihydrotestosterone in the blood is extremely important, since this androgen is responsible for the harmonious development of the organism.

Elevated dihydrotestosterone levels

The balance of hormones, male and female, is responsible for the normal functioning of the genital organs and all body systems. If the level of the hormone dihydrotestosterone in the body of a woman or a girl is elevated, then many systems fail. For example, in adolescence, girls appear the first signs of an increase in dihydrotestosterone in the body:

juvenile acne, acne,
irregular menstrual cycle or its absence,
the male skeleton develops,
formed a rough voice.

These factors are not abnormal, however, if the cycle is not restored after two years, then this may be a signal of increased dihydrotestosterone.

Hormonal disruptions of dihydrotestosterone often occur in adulthood.

Havewomen with elevated dihydrotestosterone have the following symptoms:

hair growth on the body, in particular, on the face, above the upper lip,
sweating increases
hair fall out,
body weight increases
increases sexual desire
increases the size of the clitoris and labia,
oily skin problem.

Important! The occurrence of one of these symptoms may not indicate an increased level of dihydrotestosterone in the blood, but they are one of the reasons for going to a doctor.

In men, the main signs of increased dihydrotestosterone are hair loss and aggressive behavior, as a result of the development of prostate adenoma or infertility. As for the female body,The causes of the increase in dihydrotestosterone in the blood indicate the presence of the following pathologies:

androgenic adrenal tumor,
metabolic disorders in the body of a woman,
polycystic ovaries,
infertility,
diabetes,
congenital or acquired pathological changes in the hypothalamus (the midbrain, is responsible for the work of many systems in the body, including controls the work of the adrenal glands).

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Low levels of dihydrotestosterone

It happens that the hormone dihydrotestosterone is poorly produced in women, its level is far below the norm.

The level of dihydrotestosterone decreases for several reasons:

androgen deficiency
Morris syndrome (congenital disorders in sexual development).
diabetes.

A decrease in testosterone and dihydrotestosterone levels can be determined by external signs. For example, in men with a decrease in dihydrotestosterone, hair loss, decrease in muscle mass, disproportionate development of body parts, and female-type obesity begin.

As for women, a reduced level of dihydrotestosterone is manifested by the following factors:

significantly reduced sexual desire
insomnia, fatigue,
dry skin.

Important! Only a specialist will be able to determine the true cause of the manifestation of such signs by examining the results of the analysis to determine the level of dihydrotestosterone in a woman’s blood. Perhaps the imbalance of dihydrosterone is not confirmed.

Preparation for the analysis

If you go to the doctor with the symptoms described, then he will most likely direct you to take an analysis to determine the level of dihydrotestosterone in the blood.

To analyze the level of dihydrotestosterone showed the most accurate results, it is necessary to properly prepare for it:

Analysis of the determination of dihydrotestosterone in women is best done on an empty stomach. If you can not do without food, then a person is allowed to drink tea or non-carbonated water. Dinner on the eve of the study should be light, low-fat and low-calorie.
Three days before the analysis of dihydrotestosterone in the blood, it is necessary to abandon alcoholic beverages, smoking and potent drugs.
Avoid stressful situations.
The analysis may give incorrect results if the patient did an ultrasound, x-ray, MRI or massage the day before.
Be sure to inform the specialist about taking medications, the course of which you do not have the right to interrupt.

When to pass to womenIs it best to analyze if they are at reproductive age? When examining the level of dihydrotestosterone in the blood, it is necessary to take into account which day of the cycle in a woman falls on that day.

The procedure is preferably carried out at 2-4 days after the onset of menstruation. Since the level of hormones associated with reproductive function may vary depending on the phases of the menstrual cycle.

Therapeutic activities

Any hormonal imbalance in a woman requires systemic treatment that will reduce or increase the level of dihydrotestosterone. However, there are non-pathological causes of high or low levels of dihydrotestosterone in women.

In this case, to eliminate these problems, time is needed (adolescence) and regular consultation with a doctor who will monitor the appearance of external signs of changes in dihydrotestosterone and will be able to start timely treatment in case of prolonged imbalance.

Dihydrotestosterone dysfunction occurs during pregnancy, menopause, and taking certain drugs. Goserelin, Danazol, Phenytoin and other drugs. The doctor selects drugs individually for each patient and depending on the cause of dihydrotestosterone dysfunction in the female body.

Dihydrotestosterone and hair loss are interrelated, as the production of protein compounds depends on the work of hair follicles. Therefore, a woman begins to thin and lose hair. How to lower in this case the level of dihydrotestosterone? To reduce androgen in women prescribe special drugs - blockers 5 alpha reductase.

Most commondrugs that reduce the level of dihydrotestosterone in the female body are:

Phytoestrogens (phytohormones, which are produced in plants) help to reduce the production of dihydrotestosterone: fruits of dwarf palm trees, red clover, soybean, alfalfa, mint, chamomile, sage.

Nettle , as one of the types of phytoestrogens, has a beneficial effect on reducing dihydrotestosterone levels in women. Oral contraceptives are also effective in treating the normalization of the balance of DGT in a woman's body: Yarin, Janine, Diane-35.

Important! Medications that reduce the level of dihydrotestosterone in women have a short-term effect, that is, during their administration.

In polycystic cases, if the woman is planning a pregnancy, the observing doctor can prescribe ovulation stimulants to the patient — solutions for intramuscular use (Puregon, Menogon) or tablets Klostilbegit.

If the level of dihydrotestosterone in a woman increases due to the insensitivity of tissue receptors to glucose, then it will be enough to follow a low carbohydrate diet to lose weight. Over time, the hormonal balance will gradually recover without the use of medications and the level of production of dihydrotestosterone will return to normal.

With low testosterone, the doctor usually prescribes hormonal drugs that will help replenish the body of a woman.

In some cases, the pathologies are incurable, in which case the level of dihydrotestosterone has to be constantly monitored with medical preparations.

Conclusion

Many women try to treat hair loss with folk remedies, vitamins and various cosmetic procedures, unaware of the serious problems with the production of dihydrosterone. However, symptomatic treatment does not give long-term results.

Diagnose and provide expert help with hormonal imbalance dihydrotestosterone in women can only endocrinologist. Do not self-medicate and do not neglect your health!

The functions of DHT in women and men

The main functions of DHT in the male body are associated with the formation and development of the reproductive system and sexual characteristics. Dihydrotestosterone in men has the following effects:

stimulates spermatogenesis,
inhibits the secretion of luteinizing hormone in the anterior pituitary gland,
affects the functional maturation of gonadotropic cells in the adenohypophysis,
stimulates the development of the prostate gland and external genital organs in the prenatal period, contributes to their growth during the pubertal period,
generates secondary sexual characteristics
regulates the structure and development of the skeletal system, the growth of muscle mass,
stimulates the nervous system,
regulates libido,
responsible for producing sebum,
It affects the hair follicles, is responsible for sexual growth of hair.

DHT is also produced in the female body. The main source of dihydrotestosterone production in women is the adrenal cortex, ovarian cells, the conversion of steroid hormone precursors in the liver, muscles, skin and adipose tissue.

Functions of DHT in the female body:

affects carbohydrate, protein, water and fat metabolism,
determines the development of the skeleton and skeletal muscles,
regulates perspiration,
activates the sebaceous glands,
forms libido.

The most significant increase in dihydrotestosterone is observed in adolescence, the peak of its production is 25 years. With age, the secretion of the hormone gradually decreases.

In the case of functional disturbances, it is possible to normalize the hormonal balance without medical intervention by correcting lifestyle.

up to 10 years: 5–25 pg / ml in girls and 5–50 pg / ml in boys,
from 10 to 12 years: 24–450 pg / ml in girls, 5–50 pg / ml in boys,
from 13 to 18 years: 24–450 pg / ml in girls and 250–700 pg / ml in boys,
from 18 to 50 years: 24–450 pg / ml in women and 250–990 pg / ml in men,
from 50 years: 10–181 pg / ml in women, 250–700 pg / ml in men.

Deviations in the secretion of DHT can lead to serious violations of the activities of different body systems.

Reduced DHT

Most often, a reduced hormone level is observed in men after 30-40 years.

Reasons for the reduction of DHT in men

obesity,
diabetes,
5-alpha reductase deficiency
androgen deficiency
hypogonadism (failure of the gonads).
chronic prostatitis,
Morris syndrome (testicular feminization syndrome).

Symptoms of lowering DHT in men:

female-type fat deposits (thighs, buttocks),
delayed sexual development in adolescents, disproportionate growth of limbs,
development of a figure in female proportions,
the reduced size of the penis, its anomalous structure,
slow hair growth on the face, in the groin, the armpits,
depression, emotional lability,
fast fatiguability,
lack of muscle mass
impotence, decreased sexual desire,
reproductive disorders, changes in spermogram.

Pathologies of the pituitary gland, ovaries, adrenal glands, diseases accompanied by a shortage of adipose tissue can lead to the development of androgen-deficient states in women. DHT deficiency in women is characterized by a decrease in muscle mass, mood lability, a tendency to depression, decreased libido, and a decrease in skin tone and thickness.

When dihydrotestosterone is elevated

Elevated levels of dihydrotestosterone in men may indicate the following disorders:

adrenal gland tumor
genital tumors,
benign and malignant tumors of the prostate gland,
hypergonadism (excessive hormonal activity of the sex glands),
cardiovascular diseases.

Excessive DHT can also be caused by medication containing androgens.

The main functions of DHT in the male body are associated with the formation and development of the reproductive system and sexual characteristics.

Symptoms of increased DHT in men:

Possible reasons for the increased hormone levels in women:

adrenal tumors
diabetes,
androgen-producing tumors in the adrenal glands or ovaries,
malnutrition, obesity,
pathology of the hypothalamus,
hormonal drugs.

Physiological increase or decrease of DHT is observed during puberty, in pre- and postmenopause, during pregnancy, breastfeeding.

If DHT is elevated, it can give a start to many pathologies.Excessively high levels of DHT in women are characterized by the following features:

hirsutism,
diffuse thinning of hair on the head,
excessive sweating
voice hardening
acne, seborrhea,
male skeleton development,
obesity,
hypertrophy of the clitoris and labia,
failure of the menstrual cycle, anovulation,
infertility.

The concept of hormones and their actions

Before finding out what are the reasons for the increase in dihydrotestosterone can be and what to do with it, you should remember the school course of anatomy. So, in the body of a man, androgens prevail.

There are 5 types of androgens. And only 2 types of androgen have a direct impact on the formation of men. Dihydrotestosterone is a hormone that has the most pronounced effect on receptors.

This hormone is responsible for a number of functions:

The physical development of the body of a man. In essence, DHT is responsible for a number of anabolic processes. With a sufficient content of this hormone in the blood of a man, a natural figure is preserved, that is, broad shoulders, narrow waist and hips. Dihydrotestosterone is also responsible for building muscle and helps to burn subcutaneous fat.
Sexual behavior. With sufficient DHT, the man maintains a good erection and high libido. If the level of the hormone rises or falls, then there are various failures.
The presence of secondary sexual characteristics. The sex hormone normally helps to maintain a low voice tone and the appearance of hair on the chest and abdomen. An interesting fact is that a rise in dihydrotestosterone in a man causes baldness.
Normal functioning of the prostate gland. With increased levels of DHT in the blood, prostate tissue begins to grow. In this case, we are already talking about prostate adenoma. In severe cases, a malignant tumor develops.

The normal value of dihydrotestosterone in men aged 15 years is 250-990 pg / ml. With the increase or decrease of these indicators, we are already talking about pathology.

Why does DHT increase?

Elevated levels of dihydrotestosterone are observed in men who used anabolic steroids in order to build muscle. It must be remembered that it is extremely dangerous to use hormone preparations without the need.

This is due to the fact that after such a course, free testosterone is converted into estrogen, and the synthesis of its own testosterone is reduced. The level of prolactin, estradiol and estrogen after taking anabolic steroids increases. This is fraught with the development of hormonal failure.

To avoid this, it is better to use natural testobusters to increase power performance. They will help increase the strength and level of free testosterone in the blood without harm to health. The most acceptable from the point of view of security is considered to be testoster Yarsagumba Forte.

If dihydrotestosterone is elevated, the reasons may be different:

Itsenko-Cushing disease. Under this abbreviation means a disease in which the pituitary microadenoma is formed.
The appearance of malignant tumors in the adrenal glands. But an increase in DHT may occur even in cases where the tumor is not malignant.
Testosterone toxicosis. Under this abbreviation means pathology, in which there is congenital hyperplasia of Leydig cells.
Benign prostatic hyperplasia. When this disease occurs, dysuric disorders are observed. In all cases, there is an increased level of dihydrotestosterone. Moreover, the indicators may increase both with time and in the initial stages of progression of BPH.

Increases in dihydrotestosterone in men are also observed in the presence of Morris syndrome. Moreover, in this disease a person with a Y chromosome may have a developed vagina.

Symptoms and diagnosis

In cases where dihydrotestosterone is elevated in a man, feminization is observed. The patient has a noticeable decrease in the percentage of muscle mass, slower growth of hair on the face and body, decreased libido. Almost always there is a flaccid member or erectile dysfunction.

In neglected clinical cases, the picture is even more pronounced. There is swelling of the mammary glands. Often the nipples hurt and itch. It happens that the increase in DHT affects the skin. For example, acne and rashes can appear on the skin.

The reasons for increased dihydrotestosterone in men can be many. Therefore, the principle of diagnosis is selected individually on the basis of the findings of the attending physician. But in all cases, in the presence of feminization symptoms, an analysis of the DHT level is prescribed.

For the analysis to be reliable, the patient needs to:

On the day of delivery of the analysis of the sex hormone do not eat food. You can only drink water without gas.
2-3 days before the analysis, abstain from alcohol and smoking.
1-2 days prior to analysis, refrain from eating fatty foods.
Stop using hormones and other medicines that may distort the results of the analysis.

Based on the test results, the physician determines the root cause of the increase in DHT, and selects the appropriate therapy.

What to do with elevated levels of DHT?

To treat the clinical cases where dihydrotestosterone in men is elevated, you need a complex. If neoplasms in the adrenal glands cause an increase in DHT, surgical treatment is prescribed. If necessary, after the procedure, radiation therapy and chemotherapy are used.

If there is an increased activity of 5-alpha-reductase, and dihydrotestosterone is increased, 5-alpha reductase inhibitors are used. Commonly used drugs such as Avodart, Finasteride, Dutasteride.

To lower the level of DHT can also be used drugs with a pronounced antiandrogenic effect. They come in 2 types:

Steroid. The most effective antiandrogens from this group are Spironolactone, Tsiproteron acetate, Megestrol acetate.
Non-steroidal. Among non-steroidal antiandrogens, Casodex, Anandron, Flutamide are the best.

If DHT is elevated in a boy, then synthetic analogs Lutropin-Release-hormone of prolonged action are used.

Treatment of elevated levels of DHT due to Itsenko-Cushing's disease, testosterone toxicosis, congenital anomalies of steroidogenesis is produced by medication.

But not always with the help of drugs can achieve high results. For example, Itsenko-Cushing's disease can be treated with adrenalectomy or proton therapy. The highest result can be achieved if you use the destruction of the adrenal glands by introducing a contrast agent that destroys their structure.

As is known, elevated DHT is very often the result of prostatitis and adenoma. The treatment of these male diseases is carried out with medication. For this purpose, bioregulatory peptides, antibiotics, 5-alpha reductase inhibitors, alpha-1-blockers, analgesics, antispasmodics are used.

How to lower dihydrotestosterone

To reduce dihydrotestosterone it is necessary to suppress the activity of the enzyme synthesizing it - 5-alpha reductase. For this, 2 types of drugs are used (DHT blockers): based on finasteride and dutasteride.

Finasteride ("Penester" and "Proscar" - tablets containing 5 mg of active ingredient, "Propecia" - 1 mg) is a selective enzyme inhibitor (blocks 5-alpha reductase type 2), is most effective for prostatic hyperplasia and baldness. When finasteride is used, serum DHT drops by about 70%. The therapeutic effects of dihydrotestosterone levels decrease after 3 months of coursework - a noticeable decrease in the prostate volume is recorded, the greasiness of the scalp and face is normalized.

Reduces the level of dihydrotestosterone in the blood and tissues of the prostate gland. Inhibits the stimulating effect of DHT on the development of prostate adenoma. The price in pharmacies is about 500 rubles

From the negative effects of taking finasteride, there is a decrease in the weight of the epididymis, worsening of the morphology and mobility of sperm, the appearance of depression, chronic anxiety. When the course is canceled, the symptoms of hyperplasia return in 6-8 months. In the first year of treatment, men may develop impotence, a pronounced decrease in libido (“post-finasteride syndrome”). After 2-4 years of treatment, this side effect usually subsides, but not always.

Dutasteride (Avodart, Urofil, Alfinale) is a 2nd generation inhibitor that blocks 1 and 2 types of 5-alpha reductase isoenzymes. The level of dihydrotestosterone is reduced to a minimum after 1-2 weeks of administration. This substance more effective than finasteride − the level of serum dihydrotestosterone is reduced by 95%. Dutasterid-based preparations are often used in bodybuilding to level the androgenic side effects of some steroids (alopecia, increased oily skin of the scalp and face, acne). But it also notes a negative effect in the form of a decrease in overall endurance and muscle mass, deterioration of potency. Some men, due to severe erectile dysfunction, are forced to take Viagra. The development of gynecomastia is also possible due to the suppression of the anti-estrogenic protection of dihydrotestosterone. Common side effects of taking both types of blockers are also swelling, itching, urticaria, and rashes.

In addition to inhibitors of 5-alpha reductase to reduce dihydrotestosterone in some cases use antiandrogenic substances: flutamide, spironolactone.

As a local therapy for the treatment of baldness use "Minocsedil", produced in the form of a spray or solution. In extreme cases, the hair follicles are transplanted from androgen-independent zones.

To reduce the level of dihydrotestosterone in young men, doctors try not to use hormonal drugs in order not to provoke androgen deficiency. Reduce the level of active hormone can help folk remedies and dietary supplements:

Stinging nettle,
Dwarf palm fruit extract: “Prostaplant”, “Permixon”, “Prostakur”,
Vitamin B and zinc also contribute to a decrease in the activity of 5-alpha reductase. To enrich the body with these elements in the diet should include fish, beef liver, legumes, soy, pumpkin seeds.

With the ineffectiveness or inappropriateness of conservative therapy, the prostate gland or adrenal neoplasms are removed.

Dihydrotestosterone enhancement

Increase dihydrotestosterone levels when reduced testosterone can stimulate the production of hormone or the introduction of exogenous steroids. In the first case, chorionic gonadotropin, thioctic acid, anti-estrogen preparations based on clomiphene citrate or tamoxifen are used.

If necessary, continuous replacement therapy prescribed exogenous testosterone.which can be in the form of injections, tablets, gels, hormonal ointments or transdermal patches. The drug of the last generation is Nebido. To maintain a normal level of testosterone (dihydrotestosterone, respectively), it is enough to give one injection every 3-4 months. Main advantages: there is no negative effect on the liver, kidneys and prostate gland, there are no hormonal jumps.

Daily use of testosterone patches and gels (“Androgel”) also provides an increase in the level of androgens, but these forms are not very convenient because of the need to prepare the skin, the likelihood of irritation, the inadmissibility of contact with the skin of other people (when using ointments and gels).

If a testosterone levels are normal, then dihydrotestosterone preparations are used (Andraktim gel, tablets).

How to normalize the level of DHT

The main method of treatment of disorders of secretion of DHT is drug therapy. Specific drugs and the duration of treatment is determined by the doctor.

The reduction of dihydrotestosterone in clinical practice is carried out with the help of steroid and non-steroidal androgens. These drugs inhibit the synthesis of DHT or prevent its binding to receptors of target cells. When premature sexual maturation in male children use means that can reduce the secretion of pituitary and hypothalamic hormones. If dihydrotestosterone is elevated in women, drugs are prescribed that contain metformin and spironolactone. With increased activity of 5-alpha reductase inhibitors of this enzyme are used.

If the deviation of the hormone level from the norm is associated with a tumor of the adrenal glands or testicles, surgical or radiation treatment of the neoplasm is necessary.

If the hormone level is lowered, hormone replacement therapy is prescribed.

In the case of functional impairment, it is possible to normalize the hormonal balance without medical intervention by correcting the lifestyle: playing sports, correcting body weight, normalizing the work and rest regime, refusing bad habits. To raise the level of androgens to a certain extent, a balanced diet can be used - the diet should be enriched with vitamins, trace elements and protein. It is important to avoid psycho-emotional stress, since the released cortisol under stress inhibits the synthesis of male sex hormones.

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Norm in women

It is he who ensures the harmonious development of organs and systems, endowing a man with male signs and abilities, and a woman with women.

The endocrine organs of both sexes produce a "kit" of hormones, which include both estrogen (female) and androgens (male).

The predominance of one or the other determines the sex of a person.

The presence of dihydrotestosterone in women is necessary for the regulation of:

the sebaceous glands work to ensure normal perspiration,
development and growth of bones and muscles
formation and normal hair growth,
various types of exchange
libido.

This important hormone is produced by the ovaries and adrenal cortex. The normal indicator of dihydrotestosterone in the body of a woman is from 5 to 450 pg / ml.

It depends on age:

in the body of girls up to 10 years old it contains only from 5 to 25 pg / ml,
older girls — B 24–450 pg / mg,
in the period of postmenopause, its level drops to 10-181 pg / ml.

An increase in the amount of male hormone, when it is not a pathology, is observed:

in the period of puberty of girls, when the formation of secondary sexual characteristics occurs,
in the body of pregnant women.

The relationship between dihydrotestosterone and hair loss is the most direct. It is this hormone that leads men to baldness.

On the causes of lower testosterone levels in men, read here.

What are the differences between free and total testosterone? If interested, read this article.

The reasons for the increase in dihydrotestosterone

The reason for the physiologically unjustified jump in the amount of male hormones in a female body can be:

tumor process (for example, polycystic ovarian cancer),
functional disorders in the endocrine system,
problems of carbohydrate metabolism (with glucose tolerance),
functional disorders of the liver associated with the production of globulin, the lack of which does not allow organs and systems to obtain female hormones in the right quantity,
taking hormone-containing drugs.

Healthy ovary and polycystic

The consequences can be:

violation of the menstrual cycle up to the complete absence of regul, which makes it impossible to conceive,
formation of the musculoskeletal system of the male type,
the appearance of acne and inflamed acne on the face, chest and back,
voice hardening
increased aggressiveness
hair loss on the head and their intensive growth in places not characteristic of women: on the face, chest and back,
endometrial hyperplasia, when his condition is not subject to normal secretory changes,
male obesity, with the weighting of the upper torso. Like any excessive weight gain, it can cause diabetes.

Endometrial hyperplasia of the uterus

The appearance of "male" signs in women should alert and serve as a reason for a visit to an endocrinologist to check their level of dihydrotestosterone.

All these troubles are fixable, if you correct the hormones in time and correctly.

Do I need preparation for testing?

Any journey begins with the first step, and any treatment with diagnosis. A blood test for hormones is the first step in determining the causes of excess production of dihydrotestosterone. The analysis does not require special preparation by the woman, but it is important to know that he is surrendering in the morning, on an empty stomach.

It is recommended to do this research on the 6-7 day of the "female" cycle.

A day before going to the lab you need:

stop smoking
eliminate fatty and fried foods from the diet,
avoid stress and excessive physical activity.

The attending physician should be aware of all the medications that are taken by the woman being examined. Some of them may have to be canceled for a while.

Increased dihydrotestosterone in women - treatment

Methods of dealing with excess dihydrotestosterone depend on the reasons that gave rise to it, and are selected individually.

If the basis of hormonal imbalance are functional disorders of the organs (for example, the liver), the treatment begins with the restoration of their functions.

In other cases, hormone replacement therapy is used: estrogen is prescribed, which neutralizes the action of androgens, saving the woman from the "male" symptoms. To normalize the level of male hormones in the female body are used such drugs as:

Diethylstilbestrol - synthesized estrogen.
Diane 35 is a combined drug of estrogenic and antiandrogenic action.
Dexamethasone is a glucocorticoid of synthetic origin, which normalizes protein, carbohydrate and mineral metabolism.
Tsiproteron - androgen receptor blocker, which reduces the effect of male hormones on the body.

It happens that hormonal treatment is contraindicated in a girl. Then assigned veroshpiron. It acts in such a way that the body's sensitivity to dihydrotestosterone is simply blocked. The amount of the hormone, alas, does not decrease, but its presence in the blood does not affect anything.

If the cause of the increased level of androgens is due to tumor processes, then a decision is made about the surgical removal of tumors. Thus, the problem of excess dihydrostestosterone is removed.

For women who have obesity of varying degrees and suffer from an excess of dihydrotestosterone, therapy should begin with measures aimed at normalizing body weight: correct the diet and include in the daily plan a set of special physical exercises.

A reduction in dihydrotestosterone can also be affected by a special diet high in estrogen-rich foods:

apples and cherries of various varieties,
potatoes, carrots and other vegetables,
meat and soy products,
cereals (wheat and rice),
rich milk and cream,
Sahara.

In addition to modern medical methods of treatment, there are methods of traditional medicine. Herbalists argue that the intake of tinctures and decoctions of plants can positively affect the hormones, bringing it back to normal.

Commenting on this statement, medical specialists add that the use of traditional methods of treatment in this case can give a positive effect only with a slight hormonal imbalance.

Dihydrostestosterone in the female body is responsible for libido and hair growth.About what should be the rate of dihydrotestosterone in the blood of a woman, read this article.

The main methods for increasing testosterone in women are described in this article.

It is best to combine herbal therapy with therapy prescribed by the attending physician — there will be more benefits. The main thing is not to self-medicate, choosing "folk preparations" and setting their dosage at their discretion.

By the way, one of the simplest and most effective means of suppressing the production of dihydrotestosterone is considered the familiar tea from the usual peppermint.

The body of a woman and the norm of the hormone dihydrotestosterone

For the normal functioning of the body is important balance of hormones. The presence of estrogen contributes to the development of the reproductive system, stabilizing the menstrual cycle. Dihydrotestosterone in women performs several functions:

This hormone is produced by the adrenal glands and the ovaries. It is required by the body in small quantities. The norm of dihydrotestosterone in women depends on age and ranges from 24 to 450 pg / l.

An increase in the level of DHT immediately affects the body.

Symptoms of increased DHT: hair loss and other

First of all, those organs that are affected by DHT are directly affected. For example, dihydrotestosterone and hair loss in women are directly related. This problem, which is most often encountered with increasing levels of this hormone. If the hormone accumulates in the bulbs, their activity deteriorates, causing the hair to become brittle and greasy. Subsequently, this leads to their loss.

On the skin, excess DHT also affects the increase in fat content due to metabolic disorders. This causes obesity, especially in the upper body.

Another problem that manifests itself with an increase in dihydrotestosterone levels in men and women is the development of diabetes. This is due to the fact that the process of glucose excretion is complicated for cells.

For adolescent girls, an increase in DHT in the blood causes a change in bone development towards the male form. In addition, girls have a rougher voice, a violation of the cycle or the complete absence of menstruation. For adult women, this can cause disruption of the reproductive system, including the development of infertility.

Increased hormone levels occur:

Liver impairment can also be a cause of increased DHT in men and women. This organ produces globulin, the molecules of which interact with sex hormones.

If elevated levels of DHT persist for a long time, this can lead to serious complications. In this case, the state of the body is estimated by specialists as precancerous.

What tests to take and how to prepare for them

If a doctor has suspicions about an increase in the level of DHT in the blood, he prescribes a special analysis.

This will determine the level of the hormone and the reasons for its increase. Assign test delivery when the patient is present:

In addition, this analysis is taken by adolescents to determine the level of hormones and their impact on the development of the reproductive system.

He does not require special training. Collection occurs in the morning on an empty stomach. Doctors are advised to exclude the use of fatty and fried foods, smoking, intense physical exertion just before taking the test.

Required to notify the doctor about taking medications. In some cases, it is recommended to suspend their use for several days before collecting tests.

Treatment of elevated levels of DHT: a procedure for reducing drug and folk remedies

The treatment is chosen individually, depending on the causes of the disease. If dihydrotestosterone is elevated in a woman planning a pregnancy, then she is prescribed medications to stimulate ovulation.

Otherwise, hormonal drugs are used to prevent conception.They have a depressant effect on androgens.

In cases where the cause of the disease is cell insensitivity to glucose, in combination with increased weight, a low carbohydrate diet is suggested as a treatment. It will get rid of extra pounds and normalize hormonal balance.

For more complex diseases that cause an increase in dihydrotestosterone levels in women: treatment with metformin, and in gynecology, spironolactone. Their effectiveness is due to the inhibition of the process of converting testosterone to DHT.

For a comprehensive and effective treatment, it is necessary to undergo examination and receive recommendations from an endocrinologist.

Dihydrotestosterone in men imbalance and what to do with increasing

Dihydrotestosterone is a very important hormone for the male body. It is a product of the synthesis of testosterone and enzymes that interact with it.

He is responsible for erection, growth of the genitals and prostate, proper maturation in adolescence.

DHT production occurs in the testicles, and the greatest concentration of a substance is concentrated in the epithelial lining of the genitals and hair follicles.

Dihydrotestosterone is present in the body of women and men, even from the moment of being in the womb. In the course of life, in men, its number increases in waves.

In the first week after birth, the level of hormone in boys is from 2.5 to 10 μm / l, then it decreases and up to three years of age its content is about 0.6 μm / l.

By 6 years, the value rises to 5 μm / l, and by 8 it is halved. In adolescence, its concentration in the blood gradually increases from 2.5 to 10 microns / l.

The highest value of dihydrotestosterone is reached at the age of 25 years, after which there is a decrease of about 2–3% per year.

While the fetus is in the womb, the substance affects the development of the testes and external genitalia. In the pubertal period, the level of DHT increases, the testes are stimulated, the genitals are actively developed, secondary sex characteristics are formed, the production of sperm begins.

Dihydrotestosterone in the male body stimulates the neuromuscular system, the function of the sebaceous glands and hair follicles, is responsible for hair growth. Hormone is important for the normal functioning of the reproductive system, it is responsible for sexual desire, arousal and sexual sensations.

The rate of this steroid substance in the blood varies with age, and is greatly reduced in older men. If the level of DHT deviates from the norm at a young age, this leads to various consequences, including prostate adenoma.

How deviations appear

Synthesis of the hormone DHT in the male body is reduced and symptoms appear that speak of imbalance and its lack. To control the specialists set standards in each age, depending on various factors. Lowering or raising which leads to abnormalities in the body.

The low value of this hormone leads to:

delayed puberty in adolescents,
the absence of secondary sexual characteristics,
limb lengthening
increase in hips
reduced muscle mass
reduction of sexual desire
impotence
infertility
obesity
diabetes mellitus
prostate adenoma,
lack of libido,
deviation of the urogenital system.

If in the body the content of DHT is exceeded, then you can observe such signs:

premature puberty,
hair loss up to balding
prostatic hyperplasia,
hirsutism,
prostate cancer.

For accurate diagnosis, you need to consult a doctor, he will conduct a study that determines the level of DHT in the body.

Dihydrotestosterone is increased in men who use steroid anabolic steroids to increase muscle mass. After such hormone therapy, free testosterone is converted to estrogen, and its own synthesis is reduced.After a course of anabolic drugs, the level of female hormones in the male body rises, such a condition can lead to hormonal failure.

The content of DHT in the blood increases for the following reasons:

Itsenko - Cushing's disease,
malignant tumor of the adrenal glands or testicles,
Leydig cell hyperplasia,
enlarged prostate gland
Morris syndrome,
hypergonadism.

Low DHT can occur if a man suffers from a congenital disorder of steroidogenesis. If the body lacks the enzyme 5-alpha reductase, then testosterone synthesis does not occur.

Children with this pathology have genital pathology.

With a decrease in DHT in a patient, the sexual life becomes indifferent, he does not feel the craving for intimacy, sexual desire disappears.

Sexual life is directly related to the functioning of the genital organs, so a decrease in its quality can lead to penile atrophy.

Decrease in the hormone dehydrotestosterone with age is fraught with deviations in the nervous, urogenital and cardiovascular systems.

Folk remedies

Also to reduce the level of the male hormone will help these popular recipes:

Freshly squeezed carrot - celery juice to drink every day, 1 glass on an empty stomach. Or you can take turns carrot and celery, the course is 2 weeks.
Tea with licorice.

It is necessary to finely chop the licorice root, add to the tea leaves and drink a cup of tea before bedtime for 14 days. Tincture of flax seeds. Take 1 tbsp. l seeds, pour boiling water with a half-bowl, a few hours, use 1 tbsp. l per day on an empty stomach.

Before using folk therapy, you should consult with a specialist.

Dihydrotestosterone in the body plays a very important role, takes part in many processes, and its deviations from the norm can lead to various pathologies and diseases.

For this reason, it is very important to monitor your health and pay attention to the warning signals, indicating the presence of deviations.

Having noticed the symptoms of a hormonal disorder, you need to seek qualified medical assistance.

How is increased dihydrotestosterone in women and how to normalize the indicators of the bioactive form of testosterone

Excess male hormones in the female body adversely affect weight, menstrual cycle, ability to conceive, elements of appearance, carbohydrate metabolism.

If the ovaries and adrenal glands malfunction, the concentration of not only testosterone increases, but also of the second active androgen. Dihydrotestosterone (DHT) is produced in the ovaries and adrenal cortex.

Deviations of the level of the male hormone quickly reflected in the state of the body.

What if dihydrotestosterone is elevated in women? The causes and symptoms of hyperandrogenism, the possible consequences, methods of treatment and prevention of pathology are described in the article.

The role of male hormones in a woman's body

The bioactive form of testosterone is involved in the regulation of many processes:

maintains sufficient bone density, supports tissue regeneration,
prevents muscle flabbiness,
affects the strength of libido,
provides an optimal layer of subcutaneous fat,
regulates the functioning of the sebaceous glands.

Dihydrotestosterone (DHT) is more active than other androgens. Deficiency of an important regulator leads to undesirable changes in the female body.

An excess of active androgen also negatively affects the reproductive system, appearance, and functioning of the body.

Unlike testosterone, DHT does not undergo changes, does not convert to estrogens and blocks a similar transformation of testosterone to increase the concentration of female sex hormones.

Causes of deviations

Any deviations in the level of DHT in the male body indicate the progression of pathologies.In fact, both too high rates and rather low results are dangerous for a patient’s health.

Dihydrotestosterone in men imbalance and what to do with increasing

Dihydrotestosterone is a very important hormone for the male body. It is a product of the synthesis of testosterone and enzymes that interact with it.

He is responsible for erection, growth of the genitals and prostate, proper maturation in adolescence.

DHT production occurs in the testicles, and the greatest concentration of a substance is concentrated in the epithelial lining of the genitals and hair follicles.

Dihydrotestosterone is present in the body of women and men, even from the moment of being in the womb. In the course of life, in men, its number increases in waves.

In the first week after birth, the level of hormone in boys is from 2.5 to 10 μm / l, then it decreases and up to three years of age its content is about 0.6 μm / l.

By 6 years, the value rises to 5 μm / l, and by 8 it is halved. In adolescence, its concentration in the blood gradually increases from 2.5 to 10 microns / l.

The highest value of dihydrotestosterone is reached at the age of 25 years, after which there is a decrease of about 2–3% per year.

How deviations appear

The low value of this hormone leads to:

delayed puberty in adolescents,
the absence of secondary sexual characteristics,
limb lengthening
increase in hips
reduced muscle mass
reduction of sexual desire
impotence
infertility
obesity
diabetes mellitus
prostate adenoma,
lack of libido,
deviation of the urogenital system.

If in the body the content of DHT is exceeded, then you can observe such signs:

premature puberty,
hair loss up to balding
prostatic hyperplasia,
hirsutism,
prostate cancer.

For accurate diagnosis, you need to consult a doctor, he will conduct a study that determines the level of DHT in the body.

Dihydrotestosterone is increased in men who use steroid anabolic steroids to increase muscle mass. After such hormone therapy, free testosterone is converted to estrogen, and its own synthesis is reduced. After a course of anabolic drugs, the level of female hormones in the male body rises, such a condition can lead to hormonal failure.

The content of DHT in the blood increases for the following reasons:

Itsenko - Cushing's disease,
malignant tumor of the adrenal glands or testicles,
Leydig cell hyperplasia,
enlarged prostate gland
Morris syndrome,
hypergonadism.

Low DHT can occur if a man suffers from a congenital disorder of steroidogenesis.If the body lacks the enzyme 5-alpha reductase, then testosterone synthesis does not occur.

Children with this pathology have genital pathology.

With a decrease in DHT in a patient, the sexual life becomes indifferent, he does not feel the craving for intimacy, sexual desire disappears.

Sexual life is directly related to the functioning of the genital organs, so a decrease in its quality can lead to penile atrophy.

Decrease in the hormone dehydrotestosterone with age is fraught with deviations in the nervous, urogenital and cardiovascular systems.

Diagnostics

If a person has elevated dihydrotestosterone, this indicates certain diseases. In order to determine the level of the hormone, blood tests are performed.
If a man has benign prostatic hyperplasia, the study is conducted to monitor the condition and track changes when taking drugs with the enzyme 5-alpha reductase.

The analysis must be taken in the morning from 8 to 11 o'clock, on an empty stomach. Before delivery, you can drink clean non-carbonated water, you should not use teas, juices, soda. In the evening you can not eat fatty, smoked, spicy foods.

1 - 2 days before passing the analysis it is necessary to exclude drinking alcohol and smoking, heavy physical exertion, including weight lifting and active sports. It is necessary to stop taking the medication, but only after consulting with the doctor.

On the eve of the analysis, it is necessary to avoid stressful situations, you should calm down and relax for an hour before it.

Contraindicated to conduct a study after the ultrasound and x-rays, as well as massage and physiotherapy. It is handed over after a certain time several times. To track the dynamics of the conditions and the time of delivery of the analysis must be exactly the same.
Acceptance of some drugs may distort the test results, so their reception must be discussed with your doctor.

At the doctor

Eliminate the cause of hormonal disruption in the body of modern medicine has not yet learned, but it is important to normalize the level of DHT in the blood in time.

If you find yourself raising or lowering the concentration of the hormone, it is recommended to consult a urologist and endocrinologist.

Methods of lowering the hormone in the body are directly related to the cause of the increase, the characteristic features of the clinical picture and the general condition of the patient.

Therapeutic agents and treatment regimen are prescribed individually, it is determined by the fact that the hormonal processes in the body are interrelated.

All the details of the work of the endocrine system are known only to a specialist, and he can also select the treatment. In most cases, medications are prescribed based on their own hormone production.

Therapy for men is selected using a variety of complex methods and means.

For example, inhibitors to 5-alpha reductase are prescribed to patients with dihydrotestosterone levels above the norm to reduce testosterone synthesis.

These include Suprefakt, Deslorelin, Buserelin, Medroxyprogesterone, Veraplex, Spironolactone.

But it is important to know that only an experienced specialist can prescribe medications and the duration of the course of treatment, self-treatment leads to an imbalance of hormones, worsens the condition and damages health.

Folk remedies

Also to reduce the level of the male hormone will help these popular recipes:

Freshly squeezed carrot - celery juice to drink every day, 1 glass on an empty stomach. Or you can take turns carrot and celery, the course is 2 weeks.
Tea with licorice.

Before using folk therapy, you should consult with a specialist.

Dihydrotestosterone in the body plays a very important role, takes part in many processes, and its deviations from the norm can lead to various pathologies and diseases.

For this reason, it is very important to monitor your health and pay attention to the warning signals, indicating the presence of deviations.

Having noticed the symptoms of a hormonal disorder, you need to seek qualified medical assistance.

How is increased dihydrotestosterone in women and how to normalize the indicators of the bioactive form of testosterone

Excess male hormones in the female body adversely affect weight, menstrual cycle, ability to conceive, elements of appearance, carbohydrate metabolism.

Deviations of the level of the male hormone quickly reflected in the state of the body.

The role of male hormones in a woman's body

The bioactive form of testosterone is involved in the regulation of many processes:

maintains sufficient bone density, supports tissue regeneration,
prevents muscle flabbiness,
affects the strength of libido,
provides an optimal layer of subcutaneous fat,
regulates the functioning of the sebaceous glands.

Dihydrotestosterone (DHT) is more active than other androgens. Deficiency of an important regulator leads to undesirable changes in the female body.

An excess of active androgen also negatively affects the reproductive system, appearance, and functioning of the body.

Unlike testosterone, DHT does not undergo changes, does not convert to estrogens and blocks a similar transformation of testosterone to increase the concentration of female sex hormones.

Causes of deviations

Increased secretion of dihydrotestosterone is a consequence of the action of pathological processes in the female body. If an increased level of androgen is detected in adolescent girls during the period of the menstrual cycle formation, then this phenomenon is permissible as long as the hormonal changes take place. Gradually, the level of the male hormone should approach normal.

If the cycle is irregular, 1–2 years after the onset of menstruation, you should consult a gynecologist to clarify the level of androgens. Against the background of untimely correction of hormonal background, with high rates of DHT, the development of polycystic ovarian disease, infertility, hirsutism, problems with the condition of the hair and the skin can occur.

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Other causes of increased dihydrotestosterone levels include:

benign tumors of the adrenal glands or ovaries,
genetic predisposition
pregnancy,
weak tissue sensitivity to the action of glucose, a violation of carbohydrate metabolism.

Clinical manifestations

Signs of excessive production of dihydrotestosterone:

the voice gets lower and rougher
the skeleton in puberty develops according to the male type,
menstruation becomes scarce, irregular, or amenorrhea develops (no monthly bleeding),
hair becomes thinner, thin, alopecia often develops,
violation of the processes in the phases of the menstrual cycle interferes with the maturation of the follicles, the release of the egg. In the absence of ovulation, conception is impossible,
on the arms and legs, the hair is thickened and darker, hirsutism develops, undesirable vegetation develops over the upper lip and in the face area,
weight is growing rapidly
there are bouts of irritability and causeless aggression,
the activity of the sebaceous glands increases, the skin becomes oily, acne appears,
the thickness of the fat layer on the hips and waist is reduced, the patient becomes less feminine.

On a note! The rate of dihydrotestosterone in women is from 24 to 450 pg / ml. Indicators are significantly lower than in men (from 250 to 990 pg / ml).

Possible consequences

Long-term excess of dihydrotestosterone in women can lead to undesirable consequences:

hirsutism
amenorrhea
violation of the menstrual cycle,
change the nature of the monthly
diabetes mellitus
increased greasiness of hair and skin,
the thinning of hair,
loss of femininity
coarse voice
insomnia,
disruption of carbohydrate metabolism, the development of diabetes,
obesity
polycystic ovary syndrome,
impaired reproductive function.

How to test for DHT

To clarify the level of dihydrotestosterone woman should come to the laboratory in the first phase of the cycle. The optimal period is from 4 to 6 days.

Rules of preparation:

before analysis (during the day) you can not drink alcohol, it is advisable not to be nervous. It is not necessary to engage in the gym or perform garden work, overwork,
on the day before the examination, food should be light, non-greasy,
in the morning you can not eat and eat
all drugs need to be taken after testing for dihydrotestosterone,
A visit to the laboratory is obligatory in the morning, not later than 11 hours,
Before taking blood, you need to calm down, relax in the office for 15–20 minutes,
On the day of the study (before the venous blood sampling), an ECG, X-ray and fluorogram, massage and physiotherapy cannot be performed.

Ways to normalize hormone levels

If you identify high levels of dihydrotestosterone, you need to find out the cause of the deviations. After eliminating the provoking factor, it is necessary to change the diet, stabilize the weight to normalize carbohydrate metabolism and hormonal balance. It is necessary to reduce the load on the nervous system, restore psycho-emotional balance.

The physician should clarify which drugs the patient is taking. If medications have been identified that stimulate the production of dihydrotestosterone, then it is necessary to find analogues or to refuse to take drugs that increase the level of active androgen.

By appointment of an endocrinologist or gynecologist, it is important to undergo a course of therapy with oral contraceptives. Pills give a good result: Janine, Yarina. With a slight deviation of DHT from the norm prescribe the drug Femoden.

To reduce the concentration of the male sex hormone, the patient takes formulations based on spironolactone and metformin. Drugs Siofor, Veroshpiron, Glyukofazh not only interfere with the transformation of testosterone into dihydrotestosterone, but also reduce blood sugar levels, normalize glucose absorption and carbohydrate metabolism.

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To reduce the concentration of dihydrotestosterone, it is useful to use products with phytoestrogens:

dairy names,
leafy greens
wheat germ
flaxseed oil and seeds,
soy
cherries
cereals,
vegetable oils,
legumes,
persimmon
nuts.

To stabilize the hormonal balance, to obtain phytoestrogens, it is useful to drink tea based on:

mint,
blackberry leaves,
Ivan-tea,
marigold,
chamomile
cuffs,
cimicifugu
oregano
alfalfa,
willow bark
angelica
lemon balm.

With the development of hyperandrogenism, it is necessary to analyze the factors against which the level of dihydrotestosterone rises.

You can not ignore the instability of the menstrual cycle, excessive hair growth on the body, excessive aggressiveness and irritability, the development of obesity.

With stabilization of dihydrotestosterone concentration, the risk of reproductive health disorders decreases, and the prerequisites for reducing glucose susceptibility decrease.

Dihydrotestosterone (DGT) in women: what it is, the norm of the hormone, how to lower

To find out what dihydrotestosterone is possible, having understood its main functions in the human body.

One of the most important male sex hormones is dihydrotestosterone (DHT). He is responsible for very important processes occurring in the body of a man:

effective work of the prostate gland,
proper development of internal and external genital organs,
uniform growth of muscle mass
formation of the skeletal system,
Hair Growth,
regulates sexual behavior and erectility.

Dihydrotestosterone is also produced in the female body. All male sex hormones are called androgens and are produced in the adrenal glands. Male female hormones are necessary for:

metabolism
growth of bones, muscles, hair,
regulation of the sebaceous and sweat glands,
formation of libido.

Deviations in the production of dihydrotestosterone in men and women, both in the direction of increasing its concentration, and with a decrease in the norm, can lead to serious violations of the activities of various body systems.

Norm hormone in men and women

To determine deviations in the secretion of DHT in the body, its regulatory indicators are used. The concentration in the blood is determined by passing a clinical analysis, the values obtained are compared with the standard.

Table of norms indicator dihydrotestosterone for men and women by age:

Reduced hormone levels - causes, symptoms, treatment options

The production of DHT in a man’s body can be reduced by various factors:

dysfunctional disorder of the gonads,
prostatitis,
diabetes,
tumors in the adrenal glands,
androgen deficiency
with Morris syndrome,
hypogonadism - the failure of the genital glands.

Hypogonodism in men

You can pay attention to your health and pass tests that determine the level of hormones, when the following symptoms occur:

sudden hair loss, cessation of their growth,
obesity manifested by the female type (abdomen, chest, thighs),
Erectile dysfunction
lack of sexual desire
excessive sweating
decrease in muscle mass
dry skin
fatigue, depression, insomnia,
infertility.

Traditionally, doctors advise to be examined if there are at least three of the above symptoms.

In boys, low hormone levels manifest as follows:

lack of muscle mass
slow hair growth, their absence on the face, in the armpits, groin,
diminished penis or its abnormal structure,
there is femininity in the figure,
disproportionate development of the limbs.

How to raise hormone levels?

Most often, a reduced hormone level is observed in men after 30–40 years old; various diseases can provoke this. When the secretion of the hormone is less than normal, you need to undergo a comprehensive examination to identify more complex pathologies. Treatment should begin with the elimination of the underlying cause.

And to increase the level of the hormone dihydrotestosterone, the endocrinologist may prescribe a replacement therapy with synthetic drugs containing testosterone.

Conversion of testosterone to dihydrotestosterone

In androgen-responsive tissues, testosterone activity increases significantly, and it begins to convert to dihydrotestosterone. This process is called testosterone conversion. The enzyme 5-alpha reductase contributes significantly to this conversion by adding two hydrogen atoms to the testosterone structure, which is why the hormone is called di-hydro-testosterone.

At the time of conversion, the link between testosterone and dihydrotestosterone is destroyed, and an active steroid is formed, which has a strong connection with androgen receptors. That is why it has a stronger effect on the male or female body.

Why an excess of hormone occurs

The presence of prostate adenoma is the most common reason for the increase in dihydrotestosterone in men.

In the course of scientific studies that were conducted with the participation of men aged 25–40 years, it turned out that everyone who had a diagnosis of prostate adenoma had dihydrotestosterone increased.

As a result of the development of a benign tumor of the tissues of the prostate gland, it increases in size and produces more hormones.

Consequences of an abnormal increase in the secretion of the hormone in the male body:

baldness, sudden hair loss,
acne
hyperexcitability,
aggressive, hot-tempered behavior
infertility developed on the background of testicular atrophy.

With increased dihydrotestosterone in women, the body reacts quite differently, there are:

increased hair growth on the face, body, male type,
excessive sweating
increased secretion of the sebaceous glands,
metabolic disorders, and as a result - obesity,
a girl may feel heightened sexual attraction
failure of the menstrual cycle
increase in the size of the clitoris and labia.

If dihydrotestosterone is elevated in women, this may indicate serious diseases:

adrenal tumors
infertility
hirsutism.

The reasons for the increase in the level of the hormone in women:

ovarian tumors
malnutrition, obesity,
taking other hormonal drugs,
congenital or acquired pathology of the hypothalamus.

Sensitivity to dihydrotestosterone is observed in women with type 2 diabetes.

Hormone blocker

In order to reduce the level of dihydrotestosterone, it is necessary to block 5-alpha reductase. Thanks to this enzyme, testosterone is converted to DHT. Dihydrotestosterone and hair loss are two interrelated concepts, since the production of an enzyme depends on the work of hair follicles.

That is why, in violation of the production of hormone hair fall out. Drugs that are prescribed to reduce the level of dihydrosterone are called 5-alpha reductase blockers. The most common are:

In addition to synthetic drugs, to reduce the production of hormone, use phytoestrogens:

fruits of dwarf palm have fatty acids, resins and tannins, which reduce the activity of hair follicles,
stinging nettle,
Red clover,
soy,
alfalfa.

Drugs that lower androgens in women

If dihydrotestosterone is high in women, the attending physician may prescribe the following drugs:

These two drugs do not just suppress the action of androgens, but prevent their production.

Often doctors may prescribe some contraceptives:

Reducing the level of the hormone drug way, it is recommended to use decoctions of herbs:

Increased dihydrotestosterone in women - causes and methods of treatment

Increased dihydrotestosterone in women happens for various reasons.

In some cases, this is due to the course of natural physiological processes, in others - the presence of pathologies in the body.

It is necessary to distinguish when a change in hormonal background is temporary and does not pose a danger, and when medical assistance is required.

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Watch the video: Testosterone in Women Mayo Clinic Womens Health Clinic (May 2024).

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Dihydrotestosterone in women and men: functions, causes of increase and decrease

The role of dihydrotestosterone in the human body

Norm and deviations

Using analysis to diagnose various diseases

Increased dihydrotestosterone in men: the causes and how to lower the level

Recommendations for preparing for the analysis

How is the treatment carried out?

Background and Functions of Dihydrotestosterone

Symptoms and causes of abnormalities

Diagnostics

What happens when balance and imbalance

Etiological factors

Course troubleshooting

Dihydrotestosterone in men: functions, normal levels and deviations

Dihydrotestosterone functions

Symptoms of abnormalities

Dihydrotestosterone and the female body

Norma dihydrotestosterone in women and men

Elevated dihydrotestosterone levels

Low levels of dihydrotestosterone

Preparation for the analysis

Therapeutic activities

Conclusion

The functions of DHT in women and men

Reduced DHT

When dihydrotestosterone is elevated

The concept of hormones and their actions

Why does DHT increase?

Symptoms and diagnosis

What to do with elevated levels of DHT?

How to lower dihydrotestosterone

Dihydrotestosterone enhancement

How to normalize the level of DHT

Norm in women

The reasons for the increase in dihydrotestosterone

Do I need preparation for testing?

Increased dihydrotestosterone in women - treatment

The body of a woman and the norm of the hormone dihydrotestosterone

Symptoms of increased DHT: hair loss and other

What tests to take and how to prepare for them

Treatment of elevated levels of DHT: a procedure for reducing drug and folk remedies

Dihydrotestosterone in men imbalance and what to do with increasing

How deviations appear

Folk remedies

How is increased dihydrotestosterone in women and how to normalize the indicators of the bioactive form of testosterone

The role of male hormones in a woman's body

Causes of deviations

Dihydrotestosterone in men imbalance and what to do with increasing

How deviations appear

Diagnostics

Folk remedies

How is increased dihydrotestosterone in women and how to normalize the indicators of the bioactive form of testosterone

The role of male hormones in a woman's body

Causes of deviations

Clinical manifestations

Possible consequences

How to test for DHT

Ways to normalize hormone levels

Dihydrotestosterone (DGT) in women: what it is, the norm of the hormone, how to lower

Norm hormone in men and women

Reduced hormone levels - causes, symptoms, treatment options

How to raise hormone levels?

Conversion of testosterone to dihydrotestosterone

Why an excess of hormone occurs

Hormone blocker

Drugs that lower androgens in women

Increased dihydrotestosterone in women - causes and methods of treatment

Watch the video: Testosterone in Women Mayo Clinic Womens Health Clinic (May 2024).

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